Mitigating Cocrystal Physical Stability Liabilities in Preclinical Formulations
نویسندگان
چکیده
منابع مشابه
Engineering cocrystal solubility, stability, and pH(max) by micellar solubilization.
Cocrystals offer great promise in enhancing drug aqueous solubilities, but face the challenge of conversion to a less soluble drug when in contact with solvent. This manuscript shows that differential solubilization of cocrystal components by micelles can impart thermodynamic stability to otherwise unstable cocrystals. The theoretical foundation for controlling cocrystal solubility and stabilit...
متن کاملRole of Excipients in Moisture Sorption and Physical Stability of Solid Pharmaceutical Formulations
Airaksinen, S.T.T., 2005. Role of excipients in moisture sorption and physical stability of solid pharmaceutical formulations. Dissertationes bioscientiarum molecularium Universitatis Helsingiensis in Viikki, 20/2005, pp. 57, ISBN 952-10-2733-9 (print) ISBN 952-10-2734-7 (pdf) ISSN 1795-7079 The interaction of moisture with pharmaceutical solids is crucial to an understanding of water-based pro...
متن کاملDiscovery Formulations: Approaches and Practices in Early Preclinical Development
Technological innovations in biology, chemistry, and medicine have provided the pharmaceutical industry a wealth of targets and molecules with the potential to treat diseases once thought intractable to drug therapy. These advances have brought about a renaissance in the industry and current estimates suggest there are more than 5,000 potential new medicines in human testing, a high percentage ...
متن کاملCarvedilol stability in paediatric oral liquid formulations
front matter & 2009 a.2010.01.002 author. : diegochiappetta@y Abstract Objective: Two carvedilol aqueous solutions and one carvedilol aqueous suspension for paediatric oral use (1mg/ml) were studied to determine their stability. Method: All samples were stored at 4, 25 and 401C. Carvedilol content of each of the three formulations was tested using high performance liquid chromatography (HPLC). ...
متن کاملStability assessment of ketoconazole in aqueous formulations.
Ketoconazole is an imidazole antifungal agent. It has a wide antifungal spectrum and possesses some antibacterial activity. In inappropriate formulations, especially in aqueous media, ketoconazole molecules may be unsteady. The stability of ketoconazole in aqueous media was assessed as a function of pH, antioxidant and ketoconazole concentrations. It was found that ketoconazole was least stable...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Pharmaceutical Sciences
سال: 2017
ISSN: 0022-3549
DOI: 10.1016/j.xphs.2016.07.018